Description. Cremophor A 6 is a whitish waxy substance. Cremophor A 25 is supplied in the form of free-flowing, non-dusting microbeads. Identity. Cremophor A. August Supersedes issue dated May MEMC e/Page 1 of 8. Cremophor® A Grades. ® = Registered trademark of BASF Aktiengesellschaft. INCI: Ceteareth-6 (and) Stearyl AlcoholThe Cremophor A grades are Combinations of Cremophor A6 and Cremophor A25 can emulsify oils with a.

Author: Dugar Zurn
Country: Lebanon
Language: English (Spanish)
Genre: Literature
Published (Last): 25 March 2008
Pages: 336
PDF File Size: 3.27 Mb
ePub File Size: 10.2 Mb
ISBN: 353-2-75609-201-2
Downloads: 76732
Price: Free* [*Free Regsitration Required]
Uploader: Maumi

J Appl Bacteriol ; We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders.

Propofol:The Challenges of Formulation | Anesthesiology | ASA Publications

When attractive forces overcome the repulsive forces, droplets adhere to each other, a state called flocculation.

James R, Glen JB: Local anesthetics, Basic and Clinical Pharmacology. Therefore, the interior is comparatively nonpolar and allows the inclusion of smaller lipophilic molecules. This formulation involves a proprietary process that brings together the oil droplet and protein to form the nanoparticles. This compound undergoes hydrolysis by alkaline phosphatase rather than by esterases. Propofol, but not thiopental, supports the growth of Candida albicans. The free fatty acids are taken up by the cells for metabolism and some become albumin bound in the circulation.

CREMOPHOR A6 – SpectraBase

Toxicological significance of parenteral drug emulsions and large-diameter tails: Properties of Cremophor EL micelles probed by fluorescence. The finding that lung concentrations of propofol were significantly higher after the administration of the propofol in the lipid-free formulation compared with the emulsion formulation led the authors to hypothesize that the emulsion formulation protected propofol from a high first-pass sequestration by the lung, possibly by maintaining more propofol in the central vascular space.


The content of such third party sites is not within our control, and we cannot and will not take responsibility for the information or content. The effect of the addition of lignocaine on propofol emulsion stability.

However, freeze—thawing and extensive shaking caused droplet enlargement.

The phosphates and nitrogen-containing cremophr are charged negative for phosphate and positive for the choline nitrogen and confer a polar character to the head group, allowing aqueous interactions that form cfemophor mechanical barrier. Cyclodextrins are cyclic oligosaccharides composed of dextrose units joined through 1—4 glycosyl bonds. In the latter case, the chylomicrons shrink in size, and their remnants are removed by the liver.

You may choose a language below to continue to this industry or close this dialog above. Propofol emulsion administration resulted in a smaller propofol volume of distribution and shorter times to peak electroencephalographic activity at onset, loss of righting reflex, and maximal electroencephalographic effects as compared with propofol administered in the lipid-free vehicle. These investigators found that droplet sizes remained on average 0. As one of the world’s leading chemical company, we combine economic success with environmental protection and social responsibility.

Emulsion degradation has been cremohor by many investigators. Paediatr Anaesth ; Studies of paclitaxel, another lipophilic drug formulated in Cremophor, have shown that after injection, the micelles in part function to slow the release of free drug.


The antioxidant potential of propofol 2,6-diisopropylphenol. Pharmaceutical emulsions cremkphor microemulsions, Pharmaceutical Dosage Forms: Propofol and postoperative pancreatitis.

The polar hydroxyl groups project to the exterior of the structure, whereas the hydrogens of the glucose units orient toward the interior of the cavity. I used this in oil part together with Cremophor A6. Schematic of a soybean oil droplet emulsified with crfmophor components. Sulfite-containing propofol emulsion as compared with EDTA-containing propofol emulsion have been found to contain larger oil droplets.

Food Addit Contam ; 9: Clinical and biochemical effects of propofol EDTA vs sevoflurane in healthy crenophor and young children. At 20 mg lidocaine, droplet enlargement 4.

Cremophor A6

Intensive Care Med ; 26 suppl 4: A change of formulation. Pancreatitis after propofol administration: Formaldehyde is both a critical endogenous metabolite as well as an exogenous toxin. Between andthe company invested 5.

Ann Pharmacother ; The company’s operations are managed crsmophor three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit. Physicochemical stability of total nutrient admixtures.

Pharm Res ; 8: