L’angor de repos: [ ] l’une de ses formes, l’angor de Prinzmetal, est un angor lié au spasme des artères coronaires; il survient la nuit, souvent. Variant angina, often termed Prinzmetal’s angina, Prinzmetal angina and less commonly vasospastic angina, angina inversa, coronary vessel spasm. L’angor de Prinzmetal est un angor spastique qui peut se révéler de façon dramatique par de graves troubles du rythme ventriculaire allant de la «mort subite.

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If these individuals have significant permanent occlusion qngor their coronary arteries, they may benefit by stenting their occluded arteries. Medical therapy prinzmetap employs vasodilator drugs, which include nitrates and calcium channel blockers. One strategy to avoid this development is to schedule nitroglycerin-free periods of between 12 to 14 hours between doses of long-acting nitroglycerin formulations.

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[Prinzmetal’s angor].

And, they should avoid any of the recreational and therapeutic drugs listed in the above Signs and symptoms sects as well as blockers of beta receptorssuch as propranololwhich, theoretically, may worsen vasospasm by sngor Beta-2 adrenergic receptor vasodilation mediated by these receptors naturally occurring stimulator, epinephrine.

Arrythmic cardiac arrest due to isolated coronary spasm is rare and there is limited information on the patients affected by this anogr alone case report. Our website uses cookies to enhance your experience. Access to the PDF text. Patients should address specific medical concerns with their physicians. These attacks were triggered by exercise or other forms of exertion and relieved by rest and nitroglycerin. American Journal of Cardiovascular Drugs: Arrhythmias are common and may be life threatening especially when the effects of vasospasm are seen in those ECG leads that reflect the potential variations of the epicardial surface of the left ventricle.


Treatment of the Kounis syndrome very much differs from that for variant angina. Prinzmetxl micrograms at 5-minute intervals is given until a positive result or a maximum dose of microg has been administered. However, coronary stenting is contraindicated in drug- refractory individuals who do not have significant organic occlusion of their coronary arteries. The mechanism that causes such intense vasospasm, as to cause a clinically significant narrowing of the coronary arteries is so far unknown, but there are three relevant hypotheses:.

Patients are predominantly younger women who may not have the classical cardiovascular risk factors except for cigarette use.

[Prinzmetal’s angor].

However, individuals commonly develop tolerancei. Unlike cases of atherosclerosis-related stable anginathese symptoms are often unrelated to exertion and occur in night or early morning hours. Definition NCI A variant form of angina pectoris caused by coronary artery vasospasm, usually occurring spontaneously and frequently associated with ST segment elevation.

Cardiac examination of individuals with variant angina is usually normal in the absence of current symptoms. Top of the page – Article Outline. Some individuals with otherwise typical variant angina may show depressions, rather than elevations in the ST segments of their ECGs during angina pain; they may also show new U waves on ECGs during angina attacks.

Endothelial dysfunction has been considered as primarily responsible for PVA. Vascular Medicine London, England.

Vasospastic Angina

As maintenance therapy, sublingual nitroglycerin tablets can be taken min before conducting activity that causes angina by the small percentage of patients who experience angina infrequently and only when doing such activity. In which subject field? Spasm of the large- or medium-sized coronary arteries.

Variant angina, originally described by Angro, is characterized by rest pain accompanied by transient ST segment changes often ST elevation resembling acute myocardial infarction, although ST depression can also occur and ventricular arrhythmias. It usually occurs spontaneously, and unlike typical angina, it nearly always occurs when a person is at rest and does not require physical exertion.


Purchase access Subscribe to the journal. Retrieved 2 April William Heberden is credited with being the first to describe in a publication prinzmetl occurrence of chest pain attacks i.

Retrieved April 28, Documentation by coronary arteriography”. A variant form of angina pectoris”. Endocarditis infective endocarditis Subacute bacterial endocarditis non-infective endocarditis Libman—Sacks endocarditis Nonbacterial thrombotic endocarditis.

In contrast to patients with angina pectoris secondary to coronary artery atherosclerosis, people with variant angina are generally younger and have fewer risk factors for coronary artery disease except for smokingwhich is a common and very significant risk factor for both types of angina.

Cardiovascular disease heart I00—I52— Individuals with variant angina my have many undocumented episodes of symptom-free coronary artery spasm that are associated with poor blood flow to portions of the heart and subsequent irregular and potentially serious heart arrhythmias.

Search Bing for all related images. Purchase access Subscribe prinsmetal JN Learning for one year. A significant percentage of patients with variant angina have asymptomatic i.

When PVA is associated with coronary atherosclerosis, the prognosis is determined by the severity of the underlying disease. You can move this window by clicking on the headline. Report of a six year experience”.

Cardiac catheterisation revealed a coronary artery spasm. A review of the accessible literature shows that at least cases have been reported.