An ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or dental lamina. It may be either. Ameloblastic fibroma, is a mixed odontogenic tumor, which commonly affects young children under the age of 20 years, with the mandibular premolar-molar. ameloblastic fibroma in a 9-year-old boy has been presented along with a review of the literature. The tumor responded to conservative surgical treatment.

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Ameloblastic fibroma is a rare odontogenic tumor comprising neoplastic epithelial and mesenchymal tissues. This lesion was previously considered to be a benign lesion with fubroma limited recurrence rate and malignant transformation.

However, recent reports have suggested that this lesion has the potential for recurrence and malignant transformation. In this brief report, we report a case of AF in the context of its high cellularity on histopathological examination. Ameloblastic fibroma AF is an extremely rare true mixed benign tumor that can occur either in the mandible or maxilla.

AF was first described by Krause in Small tumors are asymptomatic, while larger ones produce significant swelling of the jaws.

On radiographs, smaller lesions are well circumscribed and unilocular with xmeloblastic sclerotic border, while larger ones are multilocular. Histopathologically, AF consists of odontogenic epithelium in the dental papilla-like background without dental hard tissue formation.

Recently, there are few reports of this condition with high recurrence rates and malignant transformation. A year-old female patient came to the Department of Oral Medicine and Radiology with a chief complaint of slowly progressive swelling on the right side of her lower posterior jaw. Patient had identified the enlargement 8 months back and her medical history was unremarkable.


On intraoral examination, the right ameloblasyic buccal vestibule was obliterated due to the expansion of the buccal cortical plate. The mucosa over the swelling was normal, except for slight blanching due to expansion of the buccal cortical plate. The lesion is seen extending from posterior aspect of first molar to the retromolar area, measuring 3 cm in size. On palpation, the swelling was slightly tender and no abnormality was ammeloblastic in the adjacent teeth.

Panoramic radiograph showed a unilocular radiolucent area with well-defined fibrpma, involving the posterior aspect of the right mandible. The lesion was measuring approximately 3. Inferiorly, the lesion was extending till the mandibular canal. Fine needle aspiration did not yield any fluid ruling out a cystic cibroma.

The lesion was enucleated and sent for histopathological examination. Microscopically, hematoxylin and eosin sections showed islands and strands of epithelial cells in a loose connective tissue stroma resembling primitive dental papilla [ Figure 1 ].

The peripheral epithelial cells lining the islands and strands were low columnar, similar to the cells found in the peripheral layer of the follicle in ameloblastoma. The connective tissue resembled cellular fibroblastic tissue similar to the dental papilla in the developing tooth. Hyaline-like tissue is also seen adjacent to the epithelial strands and islands [ Figure 2 ]. It was interesting to note that both the epithelial islands and connective tissue stroma revealed high cellularity when compared with the conventional lesions of AF.

However, severe dysplastic features such as cellular and nuclear pleomorphism and increased number of abnormal mitotic figures were not observed. In this context, immunohistochemistry for Ki [ Figure 3a ] proliferative marker along with proper positive [ Figure 3b ] and negative [ Figure 3c ] controls were performed.


Immunohistochemistry for Ki was negative as it was not taken up by the tissue.

Pathology Outlines – Benign tumors / tumor-like conditions: ameloblastic fibroma

This had ruled out the diagnosis of a malignant tumor, confirming the diagnosis of AF. To conclude, we report a rare case of AF with high cellularity. The histopathological finding of high cellularity in this lesion is fibtoma as conventional AFs show mild to moderate cellularity in a loose myxomatous connective tissue background. Our case of AF with high cellularity is unusual in the context of its histopathology.

National Center for Biotechnology InformationU. Amelloblastic Oral Maxillofac Pathol.

Ameloblastic fibroma Lalitha C H, Goyal S, Perka L, Kodangal S – J Indian Acad Oral Med Radiol

Fkbroma information Copyright and License information Disclaimer. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. This article has been cited by other articles in PMC.

Abstract Ameloblastic fibroma is a rare odontogenic tumor comprising neoplastic epithelial and mesenchymal tissues.

Ameloblastic fibroma, jaw tumors, Ki, odontogenic tumors.

Ameloblastic fibroma

Open in a separate window. Footnotes Source of Support: Treatment of large ameloblastic fibroma: Saunders Indian Print ; Text book of oral and maxillofacial pathology; pp. A review of published studies with special reference to its nature and biological behavior. Rapid sarcomatous transformation of an ameloblastic fibroma of the mandible: Case report and literature review. Articles from Journal of Oral and Maxillofacial Pathology: Support Center Support Center.

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